HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia
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چکیده
منابع مشابه
HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia.
Loss of primary cilia is a key feature of von Hippel-Lindau tumor suppressor (VHL)-associated pathology. Although VHL-deficiency predisposes cells to precipitous cilia disassembly in response to growth factor cues, it does not affect ciliogenesis. Here, using a siRNA-based screen to find genes that are essential for ciliogenesis only in the presence of the VHL tumor suppressor gene product pVHL...
متن کاملScientific Report HIF1a deubiquitination by USP8 is essential for ciliogenesis in normoxia
Loss of primary cilia is a key feature of von Hippel-Lindau tumor suppressor (VHL)-associated pathology. Although VHL-deficiency predisposes cells to precipitous cilia disassembly in response to growth factor cues, it does not affect ciliogenesis. Here, using a siRNA-based screen to find genes that are essential for ciliogenesis only in the presence of the VHL tumor suppressor gene product pVHL...
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The DNA damage response (DDR) is crucial for genomic integrity. BRIT1 (breast cancer susceptibility gene C terminus-repeat inhibitor of human telomerase repeat transcriptase expression), a tumor suppressor and early DDR factor, is recruited to DNA double-strand breaks (DSBs) by phosphorylated H2A histone family, member X (γ-H2AX), where it promotes chromatin relaxation by recruiting the switch/...
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Objective(s): Here, we examined the function of our produced monoclonal antibody (mAb10C3) to recognize one of the most important members of the HEAT shock factor family, Hsf5, in embryonic development and in spermatogenic cells of adult mouse testis.Materials and Methods: The targeting effects of mAb10C3 were investigated by immunohisto...
متن کاملCluap1 is essential for ciliogenesis and photoreceptor maintenance in the vertebrate eye.
PURPOSE To identify the mutation and cell biological underpinnings of photoreceptor defects in zebrafish au5 mutants. METHODS Whole genome sequencing and SNP mapping were used to determine the genomic interval that harbors the au5 mutation. A candidate mutation was cloned and sequenced, and mRNA rescue used to validate that the affected gene was correctly identified. In situ hybridization, im...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2013
ISSN: 1469-221X,1469-3178
DOI: 10.1002/embr.201337688